Losartan discovered ineffective in lowering hospitalization from delicate COVID-19

Losartan discovered ineffective in lowering hospitalization from delicate COVID-19

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College of Minnesota Medical Faculty researchers decided that the widespread blood strain treatment, losartan, will not be efficient in lowering hospitalization for mildly-ill COVID-19 outpatients.

Within the multicenter, randomized, double-blinded scientific trial, non-hospitalized sufferers lately identified with COVID-19 got both losartan or a placebo and monitored for 15 days. The research’s outcomes, which had been printed in EClinicalMedicine, confirmed that though losartan doesn’t scale back the chance of hospitalization, the treatment doesn’t seem to worsen signs of COVID-19 or have any important or dangerous unwanted side effects on sufferers with delicate COVID-19.

“Based mostly on our outcomes, there isn’t any profit to beginning losartan for newly identified outpatients with COVID-19, however those that are already taking the treatment for pre-existing well being circumstances ought to really feel secure persevering with it,” mentioned Michael Puskarich, MD, an affiliate professor within the Division of Emergency Drugs on the U of M Medical Faculty and co-principal investigator of this research. He’s additionally an emergency doctor at Hennepin Healthcare.

Conflicting hypotheses for the reason that begin of the pandemic led this analysis staff to analyze losartan as a possible remedy possibility. Whereas some specialists believed medication like losartan might scale back irritation and assist these contaminated get better, others fearful that the drug might worsen COVID-19 signs.

“Given SARS-CoV-2 binding with ACE2 there was important analysis curiosity into the utility of ACE and AT1R blocking brokers to fight COVID-19. This research offers perception that for sufferers with delicate COVID-19, who don’t require hospital admission, that there isn’t any profit or hurt from such brokers,” mentioned co-principal investigator Christopher Tignanelli, MD, MS, an assistant professor within the Division of Surgical procedure on the U of M Medical Faculty and demanding care surgeon with M Well being Fairview.

The identical staff has been engaged on one other trial for inpatients to guage if losartan prevents lung damage in hospitalized sufferers with COVID-19 pneumonia. They’ve accomplished enrollment and are at the moment analyzing the info.

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Extra data:
Michael A. Puskarich et al, A multi-center part II randomized scientific trial of losartan on symptomatic outpatients with COVID-19, EClinicalMedicine (2021). DOI: 10.1016/j.eclinm.2021.100957

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College of Minnesota Medical Faculty

Losartan discovered ineffective in lowering hospitalization from delicate COVID-19 (2021, June 18)
retrieved 18 June 2021
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